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Year Number of Results
2003 2
2006 1
2008 2
2009 1
2010 1
2011 2
2013 1
2014 2
2016 1
2017 1
2019 1
2021 3
2022 1
2023 1
2024 0

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19 results

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Page 1
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Lee BJ, et al. Among authors: aggen jb. Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24. Nat Chem Biol. 2021. PMID: 34168367 Free PMC article.
1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists.
Pennell AM, Aggen JB, Sen S, Chen W, Xu Y, Sullivan E, Li L, Greenman K, Charvat T, Hansen D, Dairaghi DJ, Wright JJ, Zhang P. Pennell AM, et al. Among authors: aggen jb. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1228-31. doi: 10.1016/j.bmcl.2013.01.005. Epub 2013 Jan 11. Bioorg Med Chem Lett. 2013. PMID: 23374868
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Cohen F, Aggen JB, Andrews LD, Assar Z, Boggs J, Choi T, Dozzo P, Easterday AN, Haglund CM, Hildebrandt DJ, Holt MC, Joly K, Jubb A, Kamal Z, Kane TR, Konradi AW, Krause KM, Linsell MS, Machajewski TD, Miroshnikova O, Moser HE, Nieto V, Phan T, Plato C, Serio AW, Seroogy J, Shakhmin A, Stein AJ, Sun AD, Sviridov S, Wang Z, Wlasichuk K, Yang W, Zhou X, Zhu H, Cirz RT. Cohen F, et al. Among authors: aggen jb. ChemMedChem. 2019 Aug 20;14(16):1560-1572. doi: 10.1002/cmdc.201900287. Epub 2019 Aug 5. ChemMedChem. 2019. PMID: 31283109
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
Burnett GL, Yang YC, Aggen JB, Pitzen J, Gliedt MK, Semko CM, Marquez A, Evans JW, Wang G, Won WS, Tomlinson ACA, Kiss G, Tzitzilonis C, Thottumkara AP, Cregg J, Mellem KT, Choi JS, Lee JC, Zhao Y, Lee BJ, Meyerowitz JG, Knox JE, Jiang J, Wang Z, Wildes D, Wang Z, Singh M, Smith JAM, Gill AL. Burnett GL, et al. Among authors: aggen jb. J Med Chem. 2023 Jan 12;66(1):149-169. doi: 10.1021/acs.jmedchem.2c01658. Epub 2022 Dec 19. J Med Chem. 2023. PMID: 36533617 Free PMC article.
Synthesis and spectrum of the neoglycoside ACHN-490.
Aggen JB, Armstrong ES, Goldblum AA, Dozzo P, Linsell MS, Gliedt MJ, Hildebrandt DJ, Feeney LA, Kubo A, Matias RD, Lopez S, Gomez M, Wlasichuk KB, Diokno R, Miller GH, Moser HE. Aggen JB, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4636-42. doi: 10.1128/AAC.00572-10. Epub 2010 Aug 30. Antimicrob Agents Chemother. 2010. PMID: 20805391 Free PMC article.
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Lee BJ, et al. Among authors: aggen jb. Nat Chem Biol. 2021 Nov;17(11):1209. doi: 10.1038/s41589-021-00905-4. Nat Chem Biol. 2021. PMID: 34616097 No abstract available.
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Lee BJ, et al. Among authors: aggen jb. Nat Chem Biol. 2021 Aug;17(8):925. doi: 10.1038/s41589-021-00843-1. Nat Chem Biol. 2021. PMID: 34188221 No abstract available.
Exploring the positional attachment of glycopeptide/beta-lactam heterodimers.
Long DD, Aggen JB, Chinn J, Choi SK, Christensen BG, Fatheree PR, Green D, Hegde SS, Judice JK, Kaniga K, Krause KM, Leadbetter M, Linsell MS, Marquess DG, Moran EJ, Nodwell MB, Pace JL, Trapp SG, Turner SD. Long DD, et al. Among authors: aggen jb. J Antibiot (Tokyo). 2008 Oct;61(10):603-14. doi: 10.1038/ja.2008.80. J Antibiot (Tokyo). 2008. PMID: 19168974
19 results